- 제목: Understanding Schizophrenia through Neuroscience

- 연사: 김민아 교수님 (서울대학교 의학과)

- 초청자: 김형 교수님 (서울대학교 생명과학부)/최명환 교수님(서울대학교 생명과학부)

- 일시: 2026년 4월 9일 (목) 오전 11시

- 장소: 서울대학교 관악캠퍼스 자연과학대학 500 동 1층 목암홀

- 링크: https://snu-ac-kr.zoom.us/j/89840360149?pwd=xSoRKdjq47gkLRmAnGzigHD7tOyCWa.1

 회의 ID: 898 4036 0149   암호: 12345

 - Abstract:

Schizophrenia is a complex and heterogeneous disorder characterized by diverse clinical trajectories and variable treatment outcomes. Despite advances in pharmacological and psychosocial interventions, predicting the course and treatment response remains a major clinical challenge. This variability underscores the need for biologically grounded markers that can refine diagnosis and guide individualized care.

At the Seoul Youth Clinic, we have established a longitudinal cohort designed to identify neurobiological signatures associated with psychosis onset, progression, and recovery. Using multimodal approaches, including neuroimaging and electrophysiology, our work has focused on thalamocortical dysconnectivity and mismatch negativity (MMN) as promising biomarkers that capture the core neurophysiological deficits in schizophrenia and its prodromal states.

In parallel, we have investigated electroconvulsive therapy (ECT) as a form of neuromodulation to unravel the neural mechanisms underlying the therapeutic effects of ECT and to identify the brain networks mediating symptom improvement.

By integrating these findings, we aim to move toward a biomarker-based, biotype-informed framework for personalized neuromodulation. Such an approach may ultimately help overcome the heterogeneity problem in schizophrenia and enable targeted interventions grounded in brain circuitry.